Detalhe da pesquisa
1.
Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents.
PLoS Pathog
; 15(6): e1007722, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31170268
2.
A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.
Nat Commun
; 13(1): 5746, 2022 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36180431
3.
The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple Plasmodium kinases and life cycle stages.
Sci Transl Med
; 14(667): eabo7219, 2022 10 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-36260689
4.
Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention.
Cell Chem Biol
; 29(2): 191-201.e8, 2022 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-34348113
5.
The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance.
Cell Chem Biol
; 29(5): 824-839.e6, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233174
6.
The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957.
Sci Rep
; 11(1): 1888, 2021 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33479319
7.
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Sci Transl Med
; 13(603)2021 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34290058
8.
Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery.
Cell Chem Biol
; 27(2): 158-171.e3, 2020 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31813848
9.
Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity.
Cell Chem Biol
; 27(7): 806-816.e8, 2020 07 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-32359426
10.
Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics.
Science
; 359(6372): 191-199, 2018 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29326268
11.
Dioxins and related environmental contaminants increase TDP-43 levels.
Mol Neurodegener
; 12(1): 35, 2017 05 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28476168
12.
Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity.
Nat Microbiol
; 2(10): 1403-1414, 2017 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-28808258